Initiation and control of movement in Parkinson's Disease

Idiopathic Parkinson's disease (PD) is a degenerative illness of the central nervous system associated with cell loss in the substantia nigra, leading to dysfunction of the basal ganglia. On the behavioral level, this dysfunction is obvious in motor deficits resulting in three main problems: tremor, rigor and akinesia. Epidemiological studies reveal that 1% of the population over 60 years is affected by this disease. As the proportion of old people in the population increases, the relevance of the treatment of PD for the health care system will increase.

Current treatments comprise drug therapy such as L-dopa and physical therapy. After 8 to 10 years, drug therapy tends to loose its effect, and even before this stage periods of reduced effect are often observed. However the deficits in motor performance are strongly dependent upon external and psychological factors, e.g. time of day, stressful situations and emotional state. Due to their apparent behavioral deficits, patients with PD often suffer from fear of being observed by others or performance anxiety. This causes additional emotional stress and leads to a deterioration of motor function.

The importance of psychological factors in patients with PD led to the development of a behavioral treatment consisting of several therapeutic aspects: acquisition of relaxation skills and their application in stressful situations, EMG-biofeedback, training of motor skills (e.g. gait, posture, handwriting etc) be using external cues in everyday life, by activitity schedules and social skills training. Evaluation of treatment outcome was carried out with standardized rating scales and tests assessing motor performance.

The research is done in cooperation with the Department of Neurology of the University of Tübingen.

The effectiveness of the behavioral treatment focussing on the control of motor movements was compared to the effects of non-specific psychological treatment of patients with Parkinson's disease (PD). 20 treatment sessions were held over a period of 10 weeks. Behavioral change was assessed by the Motor Performance Test Series (MPS), the Unified Parkinson's Disease Rating Scale (UPDRS), by the psychologist's ratings and patients' self reports. Unspecific placebo-like effects were ruled out using data from several questionnaires. Results indicated that only behavioral treatment was effective in reducing tremor and in improving manual dexterity. It is concluded that behavioral treatment is an effective supplement to the traditional medical treatment with L-Dopa for improving motor performance and reducing tremor in Parkinson's disease.

Mattes, R. M., Rosin, R., Birbaumer, N. & Müller, F. (1994). Verhaltenstherapeutische Ansätze zur Behandlung des Morbus Parkinson. In: Kasten, E., Janke, W. Sabel, B, A, (Hrsg.) Psychologische und Biologische Medizin. Königshausen & Neumann GmbH.

Mohr, B., Müller, V., Rosin, R., Strehl, U., Birbaumer, N. (1995). Verhaltenstherapeutisches Gruppentraining bei Morbus Parkinson: Eine Effizienzstudie. In: D. Emmans (ed.) Psychologie und Morbus Parkinson, Sammelband zur 2. Arbeitstagung, (in press).

Mohr, B., Müller, V., Mattes, R., Rosin, R., Federmann, B., Strehl, U., Pulvermüller, F., Müller, F., Lutzenberger, W. & Birbaumer, N. (1996). Behavioral treatment of Parkinson's disease leads to improvement of motor skills and to tremor reduction.Behavior Therapy, 27.

Strehl, U., Birbaumer, N. (1996) Verhaltensmedizinische Intervention bei Morbus Parkinson. Beltz, Verlag, Weinheim.

Improvement of gait in Parkinson patients after behavioral treatment

Gait patterns of patients with idiopathic Parkinson's disease were evaluated with an opto-electronic movement analysis system (ELITE) before and after psychological treatment. In Parkinson's disease gait and posture are well-known to deteriorate with progression of the disease. After a 3-month treatment interval, patients receiving behavioral treatment designed to improve initiation and control of movements needed significantly less time for initiating walking. In addition, these patients showed a significant reduction in the propensity to bend the trunk forward during walking. In contrast, matched PD patients receiving non-specific psychological treatment also showed a significant deterioration of their walking pattern over the 3-month treatment period. It can be concluded that specific behavioral treatment is effective in improving gait and postural deficits in Parkinson's disease.


Home-Page
Hubert Preißl
Maintainer: hubert.preissl@uni-tuebingen.de(hubert.preissl@uni-tuebingen.de)